Guitar Rising - Guitar Hero with real guitar

The GameTank's game Guitar Rising allows you to use your real guitar to play it. The game itself accepts virtually all audio inputs - direct audio in, microphone, or 1/4-inch-to-USB adapter and allows you to play along with the catalogue with songs on beginner and expert difficulties. On the link below you can see a video of the game.

Source: http://www.engadget.com